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In this episode, host Alyssa Watson, DVM, welcomes Charlie Pye, DVM, DVSc, DACVD, to talk about her recent Clinician’s Brief article, “Cutaneous Lymphoma in an American Pit Bull Terrier Crossbreed.” Dr. Pye covers all the essential background for cutaneous lymphoma, which can mimic many other skin diseases. She also gives practical tips for performing skin biopsies, runs through treatment options, and even negotiates the challenging terminology connected to this disease (mycosis fungoides?!).
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Key Takeaways
Cutaneous lymphoma can have a broad array of presenting lesions: erythema, scaling, depigmentation, plaques, nodules, cutaneous or mucosal ulcers, and variable pruritus.
In dogs, cutaneous lymphoma typically involves T-cells and targets the epidermis, hence the name cutaneous epitheliotropic T-cell lymphoma (non-epitheliotropic is more common in cats).
There are many possible differentials so skin biopsy is necessary; biopsy at least 3 sites (if able) and avoid sampling the center of an ulcer.
In cases of limited localized disease, surgery can be considered, but cutaneous lymphoma is often too diffuse for surgery to be practical.
The standard chemotherapeutic agent is lomustine (CCNU), and other options include retinoids, corticosteroids, or palliative oclacitinib and lokivetmab.
Treatment outcomes are not great, and dogs with atopic dermatitis are at increased risk of developing cutaneous lymphoma.
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The Team:
Alyssa Watson, DVM - Host
Alexis Ussery - Producer & Multimedia Specialist