Mycophenolate Mofetil

Andrew Bugbee, DVM, DACVIM (SAIM), Texas A&M University

Danielle Dunn, DVM, University of Georgia

ArticleLast Updated November 20154 min readPeer Reviewed
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In recent years, the indications and reported frequency of use of mycophenolate mofetil (MMF) in veterinary patients has rapidly expanded.

Clinical Applications

Clinically, MMF is used to suppress the immune system.

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  • Often used in conjunction with other immunosuppressive medications (eg, glucocorticoids) for the treatment of immune-mediated disease or prevention of tissue rejection following organ transplantation

  • Veterinary conditions in which MMF therapy has been investigated include immune-mediated hemolytic anemia, aplastic anemia, immune-mediated thrombocytopenia, glomerulonephritis, myasthenia gravis, inflammatory neurologic disease, and autoimmune dermatologic disease.<sup1-7  sup>  

  • Prospective clinical trials are warranted to confirm efficacy and better guide MMF use in veterinary patients.

    • To date, efficacy has primarily been reported retrospectively.

MMF exerts its effect primarily through inhibition of T- and B-lymphocyte proliferation and subsequent reduction in antibody production.

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