Mycophenolate Mofetil
Andrew Bugbee, DVM, DACVIM (SAIM), Texas A&M University
Danielle Dunn, DVM, University of Georgia
In recent years, the indications and reported frequency of use of mycophenolate mofetil (MMF) in veterinary patients has rapidly expanded.
Clinical Applications
Clinically, MMF is used to suppress the immune system.
Often used in conjunction with other immunosuppressive medications (eg, glucocorticoids) for the treatment of immune-mediated disease or prevention of tissue rejection following organ transplantation
Veterinary conditions in which MMF therapy has been investigated include immune-mediated hemolytic anemia, aplastic anemia, immune-mediated thrombocytopenia, glomerulonephritis, myasthenia gravis, inflammatory neurologic disease, and autoimmune dermatologic disease.<sup1-7 sup>
Prospective clinical trials are warranted to confirm efficacy and better guide MMF use in veterinary patients.
To date, efficacy has primarily been reported retrospectively.
MMF exerts its effect primarily through inhibition of T- and B-lymphocyte proliferation and subsequent reduction in antibody production.
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