Maropitant
Neurokinin-1 Receptor Antagonist, Antiemetic (Systemic Drug)
Prescriber Highlights
Veterinary-approved antiemetic for dogs 8 weeks of age or older and cats 16 weeks of age or older
Acts at the emetic center and is effective for antiemesis both peripherally and centrally
Subcutaneous injection is FDA-approved for prevention and treatment of acute vomiting in dogs and treatment of vomiting in cats
The oral dose is higher than the subcutaneous dose because of decreased oral bioavailability
Refrigerating the injectable solution may reduce pain at the injection site. Solution needs to be stored in the refrigerator after first vial puncture.
Uses, Indications
The injectable solution is indicated for dogs 8 weeks of age or older for prevention and treatment of acute vomiting
Oral tablets are indicated for prevention of acute vomiting and motion sickness with vomiting in dogs
The injectable solution is approved for treatment of vomiting in cats 16 weeks of age or older
Contraindications, Precautions, Warnings
Contraindications
If vomiting persists despite treatment, further evaluation for an underlying cause is warranted
Precautions
Use with caution in patients with hepatic disease because maropitant is hepatically metabolized
Warnings
Use with caution in puppies less than 11 weeks of age; higher frequency and greater severity of histologic evidence of bone marrow hypoplasia has been observed in puppies treated with maropitant
Side Effects
Well tolerated in most patients
Swelling and pain at the injection site have been reported in dogs following SQ administration
Pretravel vomiting and hypersalivation are the most common side effects seen after oral administration at the dose motion sickness prevention requires
Drug Interactions
Biotransformed in the liver by CYP450 enzymes and highly protein bound and therefore susceptible to various drug interactions (eg, chloramphenicol, phenobarbital, erythromycin, ketoconazole, itraconazole, NSAIDs); however, specific drug interactions have yet to be investigated
Monitoring
Clinical efficacy is measured by decreased frequency of vomiting and side effects
Client Information
Vomiting may occur after administration, so giving the medication with a small meal may help
If splitting tablets, wrap remaining portions tightly in foil until they are used
Dosage Forms
Maropitant citrate injectable solution: 10 mg/mL
Maropitant citrate oral tablets: 16 mg, 24 mg, 60 mg, 160 mg
Compiled and summarized from Plumbs Veterinary Drugs by Shannon Palermo, VMD
Information about this drug was adapted from Plumbs Veterinary Drugs. Further details and more therapeutics can be found with a subscription at plumbsveterinarydrugs.com