The Case
An 8-year-old, 71-lb (32-kg) spayed Labrador retriever is presented for 3 episodes of urinary incontinence over a 2-month period. Her owner indicates there have been no changes in appetite or energy level and no episodes of vomiting or diarrhea. There have been mild increases in water consumption, frequency of urination, and signs of anxiety over the past few months. Stranguria and hematuria have not been observed.
Physical examination and CBC results are within normal limits. Results of a nonfasting serum chemistry profile show elevations in ALP, ALT, and cholesterol (Table 1). Urinalysis shows hyposthenuria (1.006) and 2+ proteinuria with an inactive sediment.
Table 1: Serum Chemistry Profile Results*
*Bold indicates values outside the reference interval.
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Conclusion
The patient had a complete response to treatment with trilostane. PU/PD, anxiety, and urinary incontinence resolved; ACTH stimulation test results improved. A long-term monitoring plan was discussed with the owner.