Grapiprant or Carprofen for Postovariohysterectomy Analgesia in Cats?
Rebecca A. Johnson, DVM, PhD, DACVAA, University of Wisconsin
In the Literature
Teixeira LG, Vaccarin CV, Schimites PI, et al. Grapiprant or carprofen following ovariohysterectomy in the cat: analgesic efficacy, hematological, biochemical and urinalysis evaluation. J Feline Med Surg. 2022;24(8):e153-e162. doi:10.1177/1098612X221097935
The Research ...
Preoperative oral analgesics can help manage intra- and postoperative analgesic requirements. Carprofen (an NSAID that preferentially inhibits the COX-2 enzyme and thus prostaglandin E2 synthesis) and grapiprant (a specific antagonist of the prostaglandin E2 receptor EP4) can be administered orally but are considered extra-label in cats.1 Both drugs are FDA-approved for use in dogs.
Trusted content.
Tailored to you.
For free.
Create an account for free.
Want free access to the #1 publication for diagnostic and treatment information? Create a free account to read full articles and access web-exclusive content on cliniciansbrief.com.