Grapiprant or Carprofen for Postovariohysterectomy Analgesia in Cats?

Rebecca A. Johnson, DVM, PhD, DACVAA, University of Wisconsin

ArticleLast Updated November 20223 min read
cat in pain

In the Literature

Teixeira LG, Vaccarin CV, Schimites PI, et al. Grapiprant or carprofen following ovariohysterectomy in the cat: analgesic efficacy, hematological, biochemical and urinalysis evaluation. J Feline Med Surg. 2022;24(8):e153-e162. doi:10.1177/1098612X221097935


The Research ...

Preoperative oral analgesics can help manage intra- and postoperative analgesic requirements. Carprofen (an NSAID that preferentially inhibits the COX-2 enzyme and thus prostaglandin E2 synthesis) and grapiprant (a specific antagonist of the prostaglandin E2 receptor EP4) can be administered orally but are considered extra-label in cats.1 Both drugs are FDA-approved for use in dogs.

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