Differential Diagnosis: Thrombocytosis

Following are differential diagnoses for patients presented with thrombocytosis.

• Drug-induced response (eg, to vincristine, epinephrine, possibly a glucocorticoid)

• Iron deficiency

• Physiologic reaction

  • To epinephrine (eg, due to trauma, exercise, or excitement)

  • Postsplenectomy

• Primary thrombocytosis

  • Acute megakaryocytic leukemia

  • Chronic myeloproliferative disease

• Chronic basophilic leukemia

• Chronic myeloid leukemia

• Essential thrombocythemia

• Other myelodysplastic/ myeloproliferative neoplasm

• Polycythemia vera

• Primary myelofibrosis

• Pseudothrombocytosis

  • RBC ghosts or fragments, fragile leukocytes, microorganisms, or lipemia

• Reactive thrombocytosis

  • Hematopoietic/nonhematopoietic neoplasia

  • Hyperadrenocorticism

  • Infection

  • Inflammation (eg, immune-mediated or hepatobiliary disease)

  • Postsplenectomy

  • Rebound from thrombocytopenia

  • Trauma