Differential Diagnosis: Eosinophilia

Following are differential diagnoses, listed in order of likelihood, for patients presented with eosinophilia.

• Parasitic diseases

  • Ectoparasites (eg, Ctenocephalides felis, Sarcoptes scabiei)

  • Endoparasites (eg, Dirofilaria immitis, Aelurostrongylus abstrusus, Cuterebra spp, Toxoplasma gondii, ascarids)

• Allergic or hypersensitivity diseases

  • Flea allergy dermatitis

  • Atopy

  • Asthma

  • Food allergy

• Hypoadrenocorticism

• Eosinophilic bronchopneumopathy (Siberian huskies, Alaskan malamutes)

• Eosinophilic granuloma complex

• Eosinophilic enteritis

  • Feline GI eosinophilic sclerosing fibroplasia

• Hypereosinophilic syndrome (rottweilers)

• Paraneoplastic syndromes

  • Mast cell tumor

  • Lymphoma (primarily T-cell but can also be seen rarely with B-cell)

  • Squamous cell carcinoma

  • Thymoma

  • Others (eg, leiomyosarcoma, mammary carcinoma, urothelial carcinoma)

• Eosinophilic meningoencephalitis of unknown etiology

• Fungal infections (eg, Cryptococcus spp)

• Drugs

  • Methimazole/carbimazole

• Chronic eosinophilic leukemia