In the Literature

Dor C, Nixon S, Schmitz SS, et al. Efficacy and tolerance of oral versus parenteral cyanocobalamin supplement in hypocobalaminaemic dogs with chronic enteropathy: a controlled randomised open-label trial. J Small Anim Pract. 2024;65(5):317-328. doi:10.1111/jsap.13705

The Research …

Cobalamin (ie, vitamin B12) is an important intracellular cofactor. Hypocobalaminemia can result in cellular cobalamin deficiency that leads to increased methylmalonic acid (MMA) concentrations, is identified in 19% to 38% of dogs with chronic enteropathy (CE), and warrants cobalamin supplementation.^1-3 Parenteral administration of cyanocobalamin has been the main method of supplementation; however, recent studies have shown similar efficacy of oral and parenteral supplementation for achieving normal serum cobalamin and/or MMA concentrations.^4-6