Research Note: Feline Vaccine-Associated Injection Site Sarcomas

Sign in to Print/View PDF

Feline vaccine-associated injection site sarcomas (ISSs) were first reported in 1991. Although radical surgery, radiation, and chemotherapy are all used to treat these aggressive tumors, recurrence is common. Nanoparticles can provide building blocks for therapeutic mechanisms and increase ability to visualize tissue. Gold nanoparticles (AuNP) can increase the radiation dose deposited into tissue. This in vitro study evaluated the effect of AuNP on ISS cytotoxicity and colony formation. Although AuNP alone did not apparently alter short-term viability or cell cycle of ISS cells, cellular proliferation decreased significantly. Thus, AuNP shows initial promise as a long-term therapeutic to decrease ISS growth.

Source

Material from Clinician’s Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Practice Tools

Topic

Oncology

Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© 2018 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)